Self-nanomicellizing solid dispersion of edaravone: part I - oral bioavailability improvement.

ABSTRACT:

Background

Edaravone (EDR) is known for its free radical scavenging, antiapoptotic, antinecrotic, and anticytokine effects in neurological and non-neurological diseases. It is currently available clinically as Radicava^® and Radicut^®, intravenous medications, recently approved for the treatment of amyotrophic lateral sclerosis and cerebral infarction. However, the oral use of EDR is still restricted by its poor oral bioavailability (BA) due to poor aqueous solubility, stability, rapid metabolism, and low permeability. The present study reports the development of novel EDR formulation (NEF) using self-nanomicellizing solid dispersion (SNMSD) strategy with the aim to enable its oral use.

Materials and methods

The selection of a suitable carrier for the dev

SUBMITTER: Parikh A 

PROVIDER: S-EPMC6038876 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature