Influence of factor XIII activity on post-operative transfusion in congenital cardiac surgery-A retrospective analysis.

ABSTRACT:

Objectives

Coagulation factor XIII (FXIII) plays a key role in fibrin clot stabilization-an essential process for wound healing following cardiothoracic surgery. However, FXIII deficiency as a risk for post-operative bleeding in pediatric cardiac surgery involving cardiopulmonary bypass (CPB) for congenital heart disease (CHD) is controversially discussed. Thus, as primary outcome measures, we analyzed the association of pre-operative FXIII activity and post-operative chest tube drainage (CTD) loss with transfusion requirements post-operatively. Secondary outcomes included the influence of cyanosis and sex on transfusion.

Methods

Our retrospective analysis (2009-2010) encompassed a single center series of 76 cardio-surgical cases with CPB (0-17 years, mean age 5.61 years) th

SUBMITTER: Fahlbusch FB 

PROVIDER: S-EPMC6038983 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature