Study of specific nanoenvironments containing α-helices in all-α and (α+β)+(α/β) proteins.

ABSTRACT: Protein secondary structure elements (PSSEs) such as α-helices, β-strands, and turns are the primary building blocks of the tertiary protein structure. Our primary interest here is to reveal the characteristics of the nanoenvironment formed by both PSSEs and their surrounding amino acid residues (AARs), which might contribute to the general understanding of how proteins fold. The characteristics of such nanoenvironments must be specific to each secondary structure element, and we have set our goal here to gather the fullest possible description of the α-helical nanoenvironment. In general, this postulate (the existence of specific nanoenvironments for specific protein substructures/neighbourhoods/regions with distinct functionality) was already successfully explored and confirmed for some

SUBMITTER: Mazoni I 

PROVIDER: S-EPMC6039001 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature