Phase-lags in large scale brain synchronization: Methodological considerations and in-silico analysis.

ABSTRACT: Architecture of phase relationships among neural oscillations is central for their functional significance but has remained theoretically poorly understood. We use phenomenological model of delay-coupled oscillators with increasing degree of topological complexity to identify underlying principles by which the spatio-temporal structure of the brain governs the phase lags between oscillatory activity at distant regions. Phase relations and their regions of stability are derived and numerically confirmed for two oscillators and for networks with randomly distributed or clustered bimodal delays, as a first approximation for the brain structural connectivity. Besides in-phase, clustered delays can induce anti-phase synchronization for certain frequencies, while the sign of the lags is determin

SUBMITTER: Petkoski S 

PROVIDER: S-EPMC6039010 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature