Thalamocortical and intracortical laminar connectivity determines sleep spindle properties.

ABSTRACT: Sleep spindles are brief oscillatory events during non-rapid eye movement (NREM) sleep. Spindle density and synchronization properties are different in MEG versus EEG recordings in humans and also vary with learning performance, suggesting spindle involvement in memory consolidation. Here, using computational models, we identified network mechanisms that may explain differences in spindle properties across cortical structures. First, we report that differences in spindle occurrence between MEG and EEG data may arise from the contrasting properties of the core and matrix thalamocortical systems. The matrix system, projecting superficially, has wider thalamocortical fanout compared to the core system, which projects to middle layers, and requires the recruitment of a larger population of neu

SUBMITTER: Krishnan GP 

PROVIDER: S-EPMC6039052 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature