Transmission of temporally correlated spike trains through synapses with short-term depression.

ABSTRACT: Short-term synaptic depression, caused by depletion of releasable neurotransmitter, modulates the strength of neuronal connections in a history-dependent manner. Quantifying the statistics of synaptic transmission requires stochastic models that link probabilistic neurotransmitter release with presynaptic spike-train statistics. Common approaches are to model the presynaptic spike train as either regular or a memory-less Poisson process: few analytical results are available that describe depressing synapses when the afferent spike train has more complex, temporally correlated statistics such as bursts. Here we present a series of analytical results-from vesicle release-site occupancy statistics, via neurotransmitter release, to the post-synaptic voltage mean and variance-for depressing syn

SUBMITTER: Bird AD 

PROVIDER: S-EPMC6039054 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature