Predictive value of single nucleotide polymorphisms in XRCC1 for radiation-induced normal tissue toxicity.

ABSTRACT:

Purpose

X-Ray Repair Cross Complementing 1 (XRCC1) functioning in the base excision repair pathway plays an important role in the repair of DNA single-strand breaks caused by ionizing radiation. The relationship between XRCC1 polymorphisms and the risk of radiation-induced side effects on normal tissues remains controversial. Therefore, we performed a comprehensive meta-analysis to elucidate these associations.

Materials and methods

A systematic literature search was carried out in PubMed, Medline (Ovid), Embase, Web of Science, Cochrane database, and the references of relevant studies. The pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the strength of the association.

Results

A total of 40 s

SUBMITTER: Zhao J 

PROVIDER: S-EPMC6039069 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature