TSLP signaling in CD4⁺ T cells programs a pathogenic T helper 2 cell state.

ABSTRACT: Pathogenic T helper 2 (T_H2) cells, which produce increased amounts of the cytokines interleukin-5 (IL-5) and IL-13, promote allergic disorders, including asthma. Thymic stromal lymphopoietin (TSLP), a cytokine secreted by epithelial and innate immune cells, stimulates such pathogenic T_H2 cell responses. We found that TSLP signaling in mouse CD4⁺ T cells initiated transcriptional changes associated with T_H2 cell programming. IL-4 signaling amplified and stabilized the genomic response of T cells to TSLP, which increased the frequency of T cells producing IL-4, IL-5, and IL-13. Furthermore, the TSLP- and IL-4-programmed T_H2 cells had a pathogenic phenotype, producing greater amounts of IL-5 and IL-13 and other proinflammatory cytokines t

SUBMITTER: Rochman Y 

PROVIDER: S-EPMC6039124 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature