Orbital frontal cortex updates state-induced value change for decision-making.

ABSTRACT: Recent hypotheses have posited that orbital frontal cortex (OFC) is important for using inferred consequences to guide behavior. Less clear is OFC's contribution to goal-directed or model-based behavior, where the decision to act is controlled by previous experience with the consequence or outcome. Investigating OFC's role in learning about changed outcomes separate from decision-making is not trivial and often the two are confounded. Here we adapted an incentive learning task to mice, where we investigated processes controlling experience-based outcome updating independent from inferred action control. We found chemogenetic OFC attenuation did not alter the ability to perceive motivational state-induced changes in outcome value but did prevent the experience-based updating of this change.

SUBMITTER: Baltz ET 

PROVIDER: S-EPMC6039177 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature