Pathologic Response to Preoperative Therapy as a Novel Prognosticator for Ampullary and Duodenal Adenocarcinoma.

ABSTRACT:

Background

The prognostic impact of pathologic response to preoperative therapy on patients with duodenal adenocarcinoma (DA) and ampullary adenocarcinoma (AMPA) has not been established.

Methods

A retrospective review of 266 patients who underwent curative resection for DA (n = 97) or AMPA (n = 169) during 1993-2015 was performed. For patients who underwent preoperative therapy, the pathologic response was systematically evaluated and classified as major (0-49% of viable residual tumor cells) or minor (≥ 50% of viable residual tumor cells). Uni- and multivariable analyses were performed to identify predictors of pathologic response and disease-specific survival (DSS).

Results

For the 79 patients treated with preoperative therapy (DA: n = 34; AMPA: n = 45), concomitan

SUBMITTER: Yamashita S 

PROVIDER: S-EPMC6039188 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature