Ontology highlight
ABSTRACT:
SUBMITTER: Wong GS
PROVIDER: S-EPMC6039276 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nature medicine 20180528 7
The role of KRAS, when activated through canonical mutations, has been well established in cancer<sup>1</sup>. Here we explore a secondary means of KRAS activation in cancer: focal high-level amplification of the KRAS gene in the absence of coding mutations. These amplifications occur most commonly in esophageal, gastric and ovarian adenocarcinomas<sup>2-4</sup>. KRAS-amplified gastric cancer models show marked overexpression of the KRAS protein and are insensitive to MAPK blockade owing to thei ...[more]