Synergistic combination of alkylphosphocholines with peptaibols in targeting Leishmania infantum in vitro.

ABSTRACT: Anti-leishmanial treatment increasingly encounters therapeutic limitations due to drug toxicity and development of resistance. The effort for new therapeutic strategies led us to work on combinations of chemically different compounds that could yield enhanced leishmanicidal effect. Peptaibols are a special type of antimicrobial peptides that are able to form ion channels in cell membranes and potentially affect cell viability. We assayed the antileishmanial activity of two well studied helical peptaibols, the 16-residue antiamoebin and the 20-residue alamethicin-analogue suzukacillin, and we evaluated the biological effect of their combination with the alkylphosphocholine miltefosine and its synthetic analogue TC52. The peptaibols tested exhibited only moderate antileishmanial activity, ho

SUBMITTER: Fragiadaki I 

PROVIDER: S-EPMC6039304 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature