Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin.

ABSTRACT: The establishment of relative size of organs and structures is paramount for attaining final form and function of an organism. Importantly, variation in the proportions of structures frequently underlies adaptive change in morphology in evolution and maybe a common mechanism underlying selection. However, the mechanism by which growth is integrated within tissues during development to achieve proper proportionality is poorly understood. We have shown that signaling by potassium channels mediates coordinated size regulation in zebrafish fins. Recently, calcineurin inhibitors were shown to elicit changes in zebrafish fin allometry as well. Here, we identify the potassium channel kcnk5b as a key player in integrating calcineurin's growth effects, in part through regulation of the cytoplasmic

SUBMITTER: Daane JM 

PROVIDER: S-EPMC6039437 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature