CCL5-deficiency enhances intratumoral infiltration of CD8⁺ T cells in colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) is the third most common solid tumor in the world and shows resistance to several immunotherapies, particularly immune checkpoint blockade which has therapeutic effects on many other types of cancer. Cytotoxic CD8⁺ T cell has been considered as one of the main populations of effector immune cells in antitumor immunity; however, the absence of CD8⁺ T cells in the central tumor area has become a major obstacle for solid tumor immunotherapy, particularly for CRC. Thus, novel therapeutic strategies that could promote CD8⁺ T cells to accumulate in the central tumor area are urgently needed. Here, we demonstrated that CCL5-deficiency delayed tumor growth and metastasis via facilitating CD8⁺ T cells to accumulate into tumor site

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6039518 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature