The Transcription Factor Zfx Regulates Peripheral T Cell Self-Renewal and Proliferation.

ABSTRACT: Peripheral T lymphocytes share many functional properties with hematopoietic stem cells (HSCs), including long-term maintenance, quiescence, and latent proliferative potential. In addition, peripheral T cells retain the capacity for further differentiation into a variety of subsets, much like HSCs. While the similarities between T cells and HSC have long been hypothesized, the potential common genetic regulation of HSCs and T cells has not been widely explored. We have studied the T cell-intrinsic role of Zfx, a transcription factor specifically required for HSC maintenance. We report that T cell-specific deletion of Zfx caused age-dependent depletion of naïve peripheral T cells. Zfx-deficient T cells also failed to undergo homeostatic proliferation in a lymphopenic en

SUBMITTER: Smith-Raska MR 

PROVIDER: S-EPMC6039547 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature