Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia.

ABSTRACT: Telomere length (TL) in peripheral blood (PB) cells of patients with chronic myeloid leukemia (CML) has been shown to correlate with disease stage, prognostic scores, response to therapy, and disease progression. However, due to considerable genetic interindividual variability, TL varies substantially between individuals, limiting its use as a robust prognostic marker in individual patients. Here, we compared TL of BCR-ABL^-, nonleukemic CD34⁺CD38^- hematopoietic stem cells (HSC) in the bone marrow of CML patients at diagnosis to their individual BCR-ABL⁺ leukemic stem cell (LSC) counterparts. We observed significantly accelerated telomere shortening in LSC compared with nonleukemic HSC. Interestingly, the degree of LSC telomere shortening was foun

SUBMITTER: Bouillon AS 

PROVIDER: S-EPMC6039661 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature