Prenatal biochemical screening and long term risk of maternal cardiovascular disease: population based cohort study.

ABSTRACT:

Objective

To examine whether abnormal prenatal biochemical screening results are associated with an increased risk of premature cardiovascular disease after pregnancy.

Design

Population based cohort study.

Setting

The entire province of Ontario, Canada, where healthcare is universally available.

Participants

Women aged 12-55 years, without pre-existing cardiovascular disease, who underwent prenatal screening between 1993 and 2011. One pregnancy per woman was randomly selected.

Exposures

Low (≤5th centile multiple of the median) serum total chorionic gonadotropin, unconjugated estriol, and pregnancy associated plasma protein A and high (≥95th centile multiple of the median) alphafetoprotein and dimeric inhibin-A.

Main outcome measures

Composite of

SUBMITTER: Ray JG 

PROVIDER: S-EPMC6039827 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature