Risks of ovarian, breast, and corpus uteri cancer in women treated with assisted reproductive technology in Great Britain, 1991-2010: data linkage study including 2.2 million person years of observation.

ABSTRACT:

Objective

To investigate the risks of ovarian, breast, and corpus uteri cancer in women who have had assisted reproduction.

Design

Large, population based, data linkage cohort study.

Setting and participants

All women who had assisted reproduction in Great Britain, 1991-2010, as recorded by the Human Fertilisation and Embryology Authority (HFEA).

Interventions

HFEA fertility records for cohort members were linked to national cancer registrations.

Main outcome measures

Observed first diagnosis of ovarian, breast, and corpus uteri cancer in cohort members were compared with age, sex, and period specific expectation. Standardised incidence ratios (SIRs) were calculated by use of age, sex, and period specific national incidence rates.

Results

255 786

SUBMITTER: Williams CL 

PROVIDER: S-EPMC6039832 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature