Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations.

ABSTRACT:

Purpose

Auditory hallucinations (AH), typically hearing voices, are a core symptom in schizophrenia. They may result from deficits in dynamic functional connectivity (FC) between cortical regions supporting speech production and language perception that interfere with the ability to recognize self-generated speech as not coming from external sources. We tested this hypothesis by investigating dynamic connectivity between the frontal cortex region related to language production and the temporal cortex region related to auditory processing.

Methods

Resting-state fMRI scans were acquired from 18 schizophrenia patients with AH (AH+), 17 schizophrenia patients without AH (AH-) and 22 healthy controls. A multiband sequence with TR = 427 ms was adopted to provide relatively high te

SUBMITTER: Zhang W 

PROVIDER: S-EPMC6039841 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature