Alterations to task positive and task negative networks during executive functioning in Mild Cognitive Impairment.

ABSTRACT: Poor executive functioning increases risk of decline in Mild Cognitive Impairment (MCI). Executive functioning can be conceptualized within the framework of working memory. While some components are responsible for maintaining representations in working memory, the central executive is involved in the manipulation of information and creation of new representations. We aimed to examine the neural correlates of these components of working memory using a maintenance working memory and visuospatial reasoning task. Twenty-five patients with amnestic MCI and 19 elderly controls (EC) completed functional MRI during reasoning and maintenance working memory tasks. In MCI, maintenance working memory was associated with hypoactivation of right frontoparietal regions and hyperactivation of left prefro

SUBMITTER: Melrose RJ 

PROVIDER: S-EPMC6039844 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature