Association between progestin-only contraceptive use and cardiometabolic outcomes: A systematic review and meta-analysis.

ABSTRACT: Aims The association between progestin-only contraceptive (POC) use and the risk of various cardiometabolic outcomes has rarely been studied. We performed a systematic review and meta-analysis to determine the impact of POC use on cardiometabolic outcomes including venous thromboembolism, myocardial infarction, stroke, hypertension and diabetes. Methods and results Nineteen observational studies (seven cohort and 12 case-control) were included in this systematic review. Of those, nine studies reported the risk of venous thromboembolism, six reported the risk of myocardial infarction, six reported the risk of stroke, three reported the risk of hypertension and two studies reported the risk of developing diabetes with POC use. The pooled adjusted relative risks (RRs) for venous thromboemboli

SUBMITTER: Glisic M 

PROVIDER: S-EPMC6039863 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature