Pulsatile Chemotherapeutic Delivery Profiles Using Magnetically Responsive Hydrogels.

ABSTRACT: Pulsatile chemotherapeutic delivery profiles may provide a number advantages by maximizing the anticancer toxicity of chemotherapeutics, reducing off-target side effects, and combating adaptive resistance. While these temporally dynamic deliveries have shown some promise, they have yet to be clinically deployed from implantable hydrogels, whose localized deliveries could further enhance therapeutic outcomes. Here, several pulsatile chemotherapeutic delivery profiles were tested on melanoma cell survival in vitro and compared to constant (flatline) delivery profiles of the same integrated dose. Results indicated that pulsatile delivery profiles were more efficient at killing melanoma cells than flatline deliveries. Furthermore, results suggested that parameters like the duration of drug "on

SUBMITTER: Emi TT 

PROVIDER: S-EPMC6039960 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature