Identification of a new alanine racemase in Salmonella Enteritidis and its contribution to pathogenesis.

ABSTRACT:

Background

Non-typhoidal Salmonella (NTS) infections caused primarily by S. Enteritidis and S. Typhimurium particularly in immunocompromised hosts have accounted for a large percentage of fatalities in developed nations. Antibiotics have revolutionized the cure of enteric infections but have also led to the rapid emergence of pathogen resistance. New powerful therapeutics involving metabolic enzymes are expected to be potential targets for combating microbial infections and ensuring effective health management. Therefore, the need for new antimicrobials to fight such health emergencies is paramount. Enteric bacteria successfully evade the gut and colonize their hosts through specialized virulence strategies. An important player, alanine racemase is a key enzyme

SUBMITTER: Ray S 

PROVIDER: S-EPMC6040060 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature