The evolutionary signal in metagenome phyletic profiles predicts many gene functions.

ABSTRACT:

Background

The function of many genes is still not known even in model organisms. An increasing availability of microbiome DNA sequencing data provides an opportunity to infer gene function in a systematic manner.

Results

We evaluated if the evolutionary signal contained in metagenome phyletic profiles (MPP) is predictive of a broad array of gene functions. The MPPs are an encoding of environmental DNA sequencing data that consists of relative abundances of gene families across metagenomes. We find that such MPPs can accurately predict 826 Gene Ontology functional categories, while drawing on human gut microbiomes, ocean metagenomes, and DNA sequences from various other engineered and natural environments. Overall, in this task, the MPPs are highly accurate, and moreover the

SUBMITTER: Vidulin V 

PROVIDER: S-EPMC6040064 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature