Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism.

ABSTRACT:

Background

Streptomyces species produce a vast diversity of secondary metabolites of clinical and biotechnological importance, in particular antibiotics. Recent developments in metabolic engineering, synthetic and systems biology have opened new opportunities to exploit Streptomyces secondary metabolism, but achieving industry-level production without time-consuming optimization has remained challenging. Genome-scale metabolic modelling has been shown to be a powerful tool to guide metabolic engineering strategies for accelerated strain optimization, and several generations of models of Streptomyces metabolism have been developed for this purpose.

Results

Here, we present the most recent update of a genome-scale stoichiometric constraint-based model of the metabolism of Stre

SUBMITTER: Amara A 

PROVIDER: S-EPMC6040156 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature