Hypofractionated Radiotherapy Is Superior to Conventional Fractionation in an Orthotopic Model of Anaplastic Thyroid Cancer.

ABSTRACT:

Background

Anaplastic thyroid cancer (ATC) is an aggressive and highly lethal disease with poor outcomes and resistance to therapy. Despite multimodality treatment, including radiation therapy and chemotherapy, response rates remain <15%, with a median time to progression of less than three months. Recent advances in radiotherapy (RT) delivery and gene-expression profiling may help guide patient selection for personalized therapy. The purpose of this study was to characterize the response to radiation in a panel of ATC cell lines and to test alternative RT fractionation schedules for overcoming radioresistance.

Materials and methods

The cellular response to radiation was characterized based on clonogenic assays. Radiation response was correlated with microarray gene-expressi

SUBMITTER: Oweida A 

PROVIDER: S-EPMC6040202 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature