Expansion of Airway Basal Cells and Generation of Polarized Epithelium.

ABSTRACT: Airway basal stem cells are the progenitor cells within the airway that exhibit the capacity to self-renew and give rise to multiple types of differentiated airway epithelial cells. This stem cell-derived epithelium displays organized architecture with functional attributes of the airway mucosa. A protocol has been developed to culture and expand human airway basal stem cells while preserving their stem cell properties and capacity for subsequent mucociliary differentiation. This achievement presents a previously unrealized opportunity to maintain a durable supply of progenitor cells derived from healthy donors to differentiate into human primary airway epithelium for cellular and molecular-based studies. Further, basal stem cells can be harvested from patients with a specific airway disea

SUBMITTER: Levardon H 

PROVIDER: S-EPMC6040659 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature