Exome sequencing of a large family identifies potential candidate genes contributing risk to bipolar disorder.

ABSTRACT: Bipolar disorder is a mental illness with lifetime prevalence of about 1%. Previous genetic studies have identified multiple chromosomal linkage regions and candidate genes that might be associated with bipolar disorder. The present study aimed to identify potential susceptibility variants for bipolar disorder using 6 related case samples from a four-generation family. A combination of exome sequencing and linkage analysis was performed to identify potential susceptibility variants for bipolar disorder. Our study identified a list of five potential candidate genes for bipolar disorder. Among these five genes, GRID1(Glutamate Receptor Delta-1 Subunit), which was previously reported to be associated with several psychiatric disorders and brain related traits, is particularly interesting. Var

SUBMITTER: Zhang T 

PROVIDER: S-EPMC6040674 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature