High-density lipoprotein cholesterol as a therapeutic target for residual risk in patients with acute coronary syndrome.

ABSTRACT:

Objective

The current guideline recommends lowering low-density lipoprotein cholesterol (LDL-C) for the primary management of dyslipidemia in patients at high-risk of cardiovascular events. Patients who have achieved LDL-C levels below the recommended targets may still experience cardiovascular events, suggesting additional therapeutic targets beyond LDL-C. The aim of this study was to investigate whether high-density lipoprotein cholesterol (HDL-C) levels had an impact on plaque stabilization in patients with acute coronary syndrome (ACS).

Methods

This study consisted of 90 ACS patients with untreated dyslipidemia. In optical coherence tomography (OCT) analysis, a plaque with fibrous cap thickness ≦160 μm was defined as a high-risk plaque. We registered one high-risk plaque

SUBMITTER: Ozaki Y 

PROVIDER: S-EPMC6040709 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature