Dengue virus serotype distribution based on serological evidence in pediatric urban population in Indonesia.

ABSTRACT:

Background

Dengue is a febrile illness transmitted by mosquitoes, causing disease across the tropical and sub-tropical world. Antibody prevalence data and serotype distributions describe population-level risk and inform public health decision-making.

Methodology/principal findings

In this cross-sectional study we used data from a pediatric dengue seroprevalence study to describe historical dengue serotype circulation, according to age and geographic location. A sub-sample of 780 dengue IgG-positive sera, collected from 30 sites across urban Indonesia in 2014, were tested by the plaque reduction neutralization test (PRNT) to measure the prevalence and concentration of serotype-specific neutralizing antibodies according to subject age and geography. PRNT results were obtained

SUBMITTER: Sasmono RT 

PROVIDER: S-EPMC6040755 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature