Two critical positions in zinc finger domains are heavily mutated in three human cancer types.

ABSTRACT: A major goal of cancer genomics is to identify somatic mutations that play a role in tumor initiation or progression. Somatic mutations within transcription factors are of particular interest, as gene expression dysregulation is widespread in cancers. The substantial gene expression variation evident across tumors suggests that numerous regulatory factors are likely to be involved and that somatic mutations within them may not occur at high frequencies across patient cohorts, thereby complicating efforts to uncover which ones are cancer-relevant. Here we analyze somatic mutations within the largest family of human transcription factors, namely those that bind DNA via Cys2His2 zinc finger domains. Specifically, to hone in on important mutations within these genes, we aggregated somatic muta

SUBMITTER: Munro D 

PROVIDER: S-EPMC6040777 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature