Temporally feathered intensity-modulated radiation therapy: A planning technique to reduce normal tissue toxicity.

ABSTRACT:

Purpose

Intensity-modulated radiation therapy (IMRT) has allowed optimization of three-dimensional spatial radiation dose distributions permitting target coverage while reducing normal tissue toxicity. However, radiation-induced normal tissue toxicity is a major contributor to patients' quality of life and often a dose-limiting factor in the definitive treatment of cancer with radiation therapy. We propose the next logical step in the evolution of IMRT using canonical radiobiological principles, optimizing the temporal dimension through which radiation therapy is delivered to further reduce radiation-induced toxicity by increased time for normal tissue recovery. We term this novel treatment planning strategy "temporally feathered radiation therapy" (TFRT).

Methods

Temporally

SUBMITTER: Lopez Alfonso JC 

PROVIDER: S-EPMC6041138 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature