Effects of high fat or high sucrose diet on behavioral-response to social defeat stress in mice.

ABSTRACT: Stress increases risk for psychopathology, and diet may moderate the impact of stress on mental health. A "Western" diet has been linked to psychopathology in humans; animal studies also show that diet can influence negative valence behavior in the presence or absence of stress, but findings are inconsistent. Contradictions in existing studies may result from differences in macronutrient content of diets and presence of metabolic syndrome. The present study exposed mice to 10 days of high fat or high sucrose diet concurrent with social defeat stress exposure and examined negative valence behavior at acute (30 days) time points after stress/diet exposure. Predictably, stress increased negative valence behavior in the social interaction, open field, elevated zero

SUBMITTER: Eudave DM 

PROVIDER: S-EPMC6041201 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature