An Optimized Structure-Function Design Principle Underlies Efficient Signaling Dynamics in Neurons.

ABSTRACT: Dynamic signaling on branching axons is critical for rapid and efficient communication between neurons in the brain. Efficient signaling in axon arbors depends on a trade-off between the time it takes action potentials to reach synaptic terminals (temporal cost) and the amount of cellular material associated with the wiring path length of the neuron's morphology (material cost). However, where the balance between structural and dynamical considerations for achieving signaling efficiency is, and the design principle that neurons optimize to preserve this balance, is still elusive. In this work, we introduce a novel analysis that compares morphology and signaling dynamics in axonal networks to address this open problem. We show that in Basket cell neurons the design principle being optimized

SUBMITTER: Puppo F 

PROVIDER: S-EPMC6041316 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature