An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration.

ABSTRACT: Despite aging being by far the greatest risk factor for highly prevalent neurodegenerative disorders, the molecular underpinnings of age-related brain changes are still not well understood, particularly the transition from normal healthy brain aging to neuropathological aging. Aging is an extremely complex, multifactorial process involving the simultaneous interplay of several processes operating at many levels of the functional organization. The buildup of potentially toxic protein aggregates and their spreading through various brain regions has been identified as a major contributor to these pathologies. One of the most striking morphologic changes in neurons during normal aging is the accumulation of lipofuscin (LF) aggregates, as well as, neuromelanin pigments. LF is an autofluorescent

SUBMITTER: Moreno-Garcia A 

PROVIDER: S-EPMC6041410 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature