Ghrelin Ameliorates Traumatic Brain Injury by Down-Regulating bFGF and FGF-BP.

ABSTRACT: Traumatic brain injury (TBI) is a primary cause of disability and mortality. Ghrelin, a gastrointestinal hormone, has been found to have protective effects for the brain, but the molecular mechanism of these neuroprotective effects of ghrelin remains unclear. In this study, an electronic cortical contusion impactor was used to establish a rat TBI model and we investigated the effect of ghrelin on brain repair by neurological severity score and histological examination. An antibody array was employed to uncover the molecular mechanism of ghrelin's neuroprotective effects by determining the alterations of multiple proteins in the brain cortex. As a result, ghrelin attenuated brain injury and promoted brain functional recovery. After TBI, 13 proteins were up-regulated in the brain cortex, whi

SUBMITTER: Shao X 

PROVIDER: S-EPMC6041414 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature