Overexpression of miR-221 in sudden death with cardiac hypertrophy patients.

ABSTRACT:

Background

Cardiac hypertrophy is a well-known risk factor for heart failure and sudden cardiac death (SCD). On the other hand, physiological cardiac hypertrophy is often observed in young healthy men, and it is difficult to predict SCD in cardiac hypertrophy subjects who do not show symptoms of heart failure. MicroRNAs (miRNAs) widely regulate biological activity and play pivotal roles in heart failure progression. In this study, we investigated whether miRNA expression is altered in SCD with cardiac hypertrophy (SCH).

Methods

Cardiac tissues were sampled at autopsy from SCH patients, compensated cardiac hypertrophy (CCH) subjects who died of causes other than heart failure, and control cases without cardiac hypertrophy or heart failure. After histopathological examination,

SUBMITTER: Kakimoto Y 

PROVIDER: S-EPMC6041564 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature