Expression of Androgen Receptor and Cancer Stem Cell Markers (CD44⁺/CD24^- and ALDH1⁺): Prognostic Implications in Invasive Breast Cancer.

ABSTRACT:

Background

Androgen receptor (AR) has emerged as a significant prognostic marker in early breast cancer (BCa). Association of AR with cancer stem cell (CSC) markers in BCa is unknown. Aim of the present study was to evaluate the immunohistochemical expression of AR, CD44, CD24 and ALDH1 in a cohort of Pakistani patients diagnosed with invasive BCa and to correlate the expression with 5- year disease free survival.

Patients and methods

We evaluated immunohistochemical expression AR, CD44, CD24 and ALDH1 in formalin fixed paraffin embedded archival blocks of 166 cases of primary invasive BCa (stage I-III) and correlated the expression with clinicopathological variables and outcome using univariable and multivariable analysis. Survival data was computed by Kaplan Meier curves.<

SUBMITTER: Riaz N 

PROVIDER: S-EPMC6041567 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature