Specific downregulation of cystathionine β-synthase expression in the kidney during obesity.

ABSTRACT: Hydrogen sulfide (H₂ S) is recognized as a novel gasotransmitter involved in the regulation of nervous system, cardiovascular functions, inflammatory response, gastrointestinal system, and renal function. Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are the major enzymes responsible for H₂ S production through desulfuration reactions. H₂ S is reported to play a protective role in both high-fat diet (HFD)-induced obese and diabetic mice. However, the synthesizing enzyme involved is not clearly elucidated. The current study was aimed to investigate the regulation of CBS and CSE in different tissues including the kidney, liver, and epididymal fat in C57BL/6 mice after a HFD (60% kcal fat) for 24 weeks. The protein and mRNA expression of CBS w

SUBMITTER: Liu M 

PROVIDER: S-EPMC6041699 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature