Principal metabolic flux mode analysis.

ABSTRACT:

Motivation

In the analysis of metabolism, two distinct and complementary approaches are frequently used: Principal component analysis (PCA) and stoichiometric flux analysis. PCA is able to capture the main modes of variability in a set of experiments and does not make many prior assumptions about the data, but does not inherently take into account the flux mode structure of metabolism. Stoichiometric flux analysis methods, such as Flux Balance Analysis (FBA) and Elementary Mode Analysis, on the other hand, are able to capture the metabolic flux modes, however, they are primarily designed for the analysis of single samples at a time, and not best suited for exploratory analysis on a large sets of samples.

Results

We propose a new methodology for the analysis of metabolism, ca

SUBMITTER: Bhadra S 

PROVIDER: S-EPMC6041797 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature