Prenatal Ethanol Exposure and Neocortical Development: A Transgenerational Model of FASD.

ABSTRACT: Fetal Alcohol Spectrum Disorders, or FASD, represent a range of adverse developmental conditions caused by prenatal ethanol exposure (PrEE) from maternal consumption of alcohol. PrEE induces neurobiological damage in the developing brain leading to cognitive-perceptual and behavioral deficits in the offspring. Alcohol-mediated alterations to epigenetic function may underlie PrEE-related brain dysfunction, with these changes potentially carried across generations to unexposed offspring. To determine the transgenerational impact of PrEE on neocortical development, we generated a mouse model of FASD and identified numerous stable phenotypes transmitted via the male germline to the unexposed third generation. These include alterations in ectopic intraneocortical connectivity, upregulation of n

SUBMITTER: Abbott CW 

PROVIDER: S-EPMC6041800 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature