Multicontact Co-operativity in Spike-Timing-Dependent Structural Plasticity Stabilizes Networks.

ABSTRACT: Excitatory synaptic connections in the adult neocortex consist of multiple synaptic contacts, almost exclusively formed on dendritic spines. Changes of spine volume, a correlate of synaptic strength, can be tracked in vivo for weeks. Here, we present a combined model of structural and spike-timing-dependent plasticity that explains the multicontact configuration of synapses in adult neocortical networks under steady-state and lesion-induced conditions. Our plasticity rule with Hebbian and anti-Hebbian terms stabilizes both the postsynaptic firing rate and correlations between the pre- and postsynaptic activity at an active synaptic contact. Contacts appear spontaneously at a low rate and disappear if their strength approaches zero. Many presynaptic neurons compete to make strong synaptic c

SUBMITTER: Deger M 

PROVIDER: S-EPMC6041941 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature