Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells.

ABSTRACT: Lineage commitment and differentiation into CD4⁺ T cell subsets reflect an interplay between chromatin regulators and transcription factors (TF). Follicular T cell development is regulated by the Bcl6 TF, which helps determine the phenotype and follicular localization of both CD4⁺ follicular helper T cells (T_FH) and follicular regulatory T cells (T_FR). Here we show that Bcl6-dependent control of follicular T cells is mediated by a complex formed between Bcl6 and the Mi-2β-nucleosome-remodeling deacetylase complex (Mi-2β-NuRD). Formation of this complex reflects the contribution of the intracellular isoform of osteopontin (OPN-i), which acts as a scaffold to stabilize binding between Bcl6 and the NuRD complex that together regulate the genetic pro

SUBMITTER: Shen E 

PROVIDER: S-EPMC6042103 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature