Origin of slow spontaneous resting-state neuronal fluctuations in brain networks.

ABSTRACT: Resting- or baseline-state low-frequency (0.01-0.2 Hz) brain activity is observed in fMRI, EEG, and local field potential recordings. These fluctuations were found to be correlated across brain regions and are thought to reflect neuronal activity fluctuations between functionally connected areas of the brain. However, the origin of these infra-slow resting-state fluctuations remains unknown. Here, using a detailed computational model of the brain network, we show that spontaneous infra-slow (<0.05 Hz) activity could originate due to the ion concentration dynamics. The computational model implemented dynamics for intra- and extracellular K⁺ and Na⁺ and intracellular Cl^- ions, Na⁺/K⁺ exchange pump, and KCC2 cotransporter. In the network

SUBMITTER: Krishnan GP 

PROVIDER: S-EPMC6042137 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature