Novel metrics for quantifying bacterial genome composition skews.

ABSTRACT:

Background

Bacterial genomes have characteristic compositional skews, which are differences in nucleotide frequency between the leading and lagging DNA strands across a segment of a genome. It is thought that these strand asymmetries arise as a result of mutational biases and selective constraints, particularly for energy efficiency. Analysis of compositional skews in a diverse set of bacteria provides a comparative context in which mutational and selective environmental constraints can be studied. These analyses typically require finished and well-annotated genomic sequences.

Results

We present three novel metrics for examining genome composition skews; all three metrics can be computed for unfinished or partially-annotated genomes. The first two metrics, (dot-skew and cros

SUBMITTER: Joesch-Cohen LM 

PROVIDER: S-EPMC6042203 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature