ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.

ABSTRACT:

Background

The ETS transcription factor ETV4 is involved in the main steps of organogenesis and is also a significant mediator of tumorigenesis and metastasis, such as in breast cancer. Indeed, ETV4 is overexpressed in breast tumors and is associated with distant metastasis and poor prognosis. However, the cellular and molecular events regulated by this factor are still misunderstood. In mammary epithelial cells, ETV4 controls the expression of many genes, MMP13 among them. The aim of this study was to understand the function of MMP13 during ETV4-driven tumorigenesis.

Methods

Different constructs of the MMP13 gene promoter were used to study the direct regulation of MMP13 by ETV4. Moreover, cell proliferation, migration, invasion, anchorage-independent growth, and in vivo tu

SUBMITTER: Dumortier M 

PROVIDER: S-EPMC6042225 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature