Novel PAradigm to improve Inflammatory burden in end stage Renal disease (rePAIR): study protocol for a randomized controlled trial.

ABSTRACT:

Background

Given the importance of inflammation as a predictor of poor outcomes in End Stage Renal Disease (ESRD), reductions in inflammatory biomarkers have been proposed as a critical target in this population. This study targets chronic periodontitis, an oral inflammatory disease of microbial etiology causing persistent inflammation in ESRD. Unlike the previously reported episodic periodontal interventions, we propose to control periodontal inflammation with a continuous maintenance and oral health behavior modifications. We hypothesize that this strategy will improve systemic inflammation and oxidative stress, oral health and quality of life within the 6-month observation period.

Methods

The rePAIR (novel PAradigm to improve Inflammatory burden in ESRD) study is a pilot

SUBMITTER: Trivedi R 

PROVIDER: S-EPMC6042267 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature