Using the cavitation collapse time to indicate the extent of histotripsy-induced tissue fractionation.

ABSTRACT: Histotripsy is an ultrasonic tissue ablation method based on acoustic cavitation. It has been shown that cavitation dynamics change depending on the mechanical properties of the host medium. During histotripsy treatment, the target-tissue is gradually fractionated and eventually liquefied to acellular homogenate. In this study, the change in the collapse time (t _col) of the cavitation bubble cloud over the course of histotripsy treatment is investigated as an indicator for progression of the tissue fractionation process throughout treatment. A 500 kHz histotripsy transducer is used to generate single-location lesions within tissue-mimicking agar phantoms of varying stiffness levels as well as ex vivo bovine liver samples. Cavitation collapse signals are acquired with broadband h

SUBMITTER: Macoskey JJ 

PROVIDER: S-EPMC6042290 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature