Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression.

ABSTRACT:

Background

Estrogen promotes breast cancer development and progression mainly through estrogen receptor (ER). However, blockage of estrogen production or action prevents development of and suppresses progression of ER-negative breast cancers. How estrogen promotes ER-negative breast cancer development and progression is poorly understood. We previously discovered that deletion of cell cycle inhibitors p16^Ink4a (p16) or p18^Ink4c (p18) is required for development of Brca1-deficient basal-like mammary tumors, and that mice lacking p18 develop luminal-type mammary tumors.

Methods

A genetic model system with three mouse strains, one that develops ER-positive mammary tumors (p18 single deletion) and the others that develop ER-negative tumors (p16;Brca1 and p1

SUBMITTER: Wang C 

PROVIDER: S-EPMC6042319 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature