Impact of alcohol disorder and the use of illicit drugs on tuberculosis treatment outcomes: a retrospective cohort study.

ABSTRACT:

Background

Alcohol and illicit drugs are associated with the discontinuation of tuberculosis (TB) treatment and can compromise the immune system. We estimated the impact of alcohol disorder and the use of illicit drug on TB treatment outcomes, considering the interaction of both substances in patients from São Paulo state, Brazil.

Methods

This is a retrospective cohort of patients diagnosed with TB from 2011 to 2015. We estimated the relative risk (RR) of an unsuccessful outcome associated with alcohol disorder, use of illicit drugs and their interaction using a multiple regression model. We used the adjusted RR to estimate the population attributable fraction.

Results

Out of a total 77,212 TB patients, 22.2% used at least one of the substances of interest during trea

SUBMITTER: Pelissari DM 

PROVIDER: S-EPMC6042349 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature